The science
Why we built it this way.
Every choice on the label — the form, the dose, the absence of proprietary blends — is grounded in published research on magnesium and human physiology. What follows is a plain-language summary with references to the primary sources.
01 · Deficiency is common
Magnesium is a cofactor in more than 300 enzymatic reactions, including those that regulate the nervous system and sleep. Population data suggests a meaningful share of US adults consume less than the recommended daily intake from diet alone, and low magnesium status has been associated with poorer sleep quality and higher subjective stress[1].
02 · Sleep & relaxation
In a double-blind placebo-controlled trial in older adults with primary insomnia, eight weeks of daily magnesium supplementation was associated with improvements in subjective sleep measures, including sleep time and sleep efficiency, compared with placebo[2].
A 2017 systematic review of magnesium supplementation and subjective anxiety and stress concluded that the existing evidence, while limited in size, generally supports a beneficial effect on subjective anxiety in susceptible individuals — and called for larger, better-controlled trials[1].
These findings describe research on magnesium generally. They are not claims about Stilla, and they are not medical advice.
03 · Why the form matters
Not all magnesium is absorbed equally. Magnesium oxide is inexpensive and common on shelves, but studies in humans have shown its bioavailability is markedly lower than organic magnesium salts such as bis-glycinate — and it is more likely to produce a laxative effect at supplemental doses[3][4].
We use magnesium bis-glycinate for three reasons: better-absorbed in the published literature, gentler on the stomach, and paired with an amino acid (glycine) that has its own well-documented profile of use around sleep and relaxation.
04 · Why a clinical dose, fully disclosed
Studies that report benefits use specific, measurable doses of elemental magnesium — not proprietary blends. That's why our label lists 275 mg of elemental magnesium per serving, alongside the total glycinate compound weight. You can cross-reference the dose against the literature.
The recommended dietary allowance for adults is approximately 310–420 mg of elemental magnesium per day from all sources (US NIH Office of Dietary Supplements). Our nightly serving is designed to complement dietary intake, not replace it.
References
- [1]Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress — A Systematic Review. Nutrients 2017;9(5):429. https://www.mdpi.com/2072-6643/9/5/429
- [2]Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences 2012;17(12):1161–1169. https://pubmed.ncbi.nlm.nih.gov/23853635/
- [3]Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN J Parenter Enteral Nutr 1994;18(5):430–435. https://pubmed.ncbi.nlm.nih.gov/7815675/
- [4]Pardo MR, Garicano Vilar E, San Mauro Martín I, et al. Bioavailability of magnesium food supplements: A systematic review. Nutrition 2021;89:111294. https://doi.org/10.1016/j.nut.2021.111294
This page is educational and summarizes publicly available peer-reviewed research on magnesium. It is not medical advice, and no statement here should be read as a claim that Stilla diagnoses, treats, cures, or prevents any disease. These statements have not been evaluated by the Food and Drug Administration.
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